Cone snail venom could trick mate-seeking worms into changing into meals

Usually, it takes the ghostly mild of the total moon to coax sure worms from hiding on the seafloor to mate. Out within the open, sex-inducing chemical compounds kick off a swirling dance that culminates in a moonlit bathe of eggs and sperm.

However only a whiff of cone snail venom may additionally get the worms within the temper.

Conus imperialis venom accommodates two molecules that mimic bristle worm pheromones and might stimulate mating behaviors, researchers report March 12 in Science Advances. The discover raises the chance that the cone snails are “weaponizing the worms’ personal pheromone as a form of lure,”says Joshua Torres, a medicinal chemist on the College of Copenhagen. “It’s actually wild.”

Cone snails pack their potent venom into self-made harpoons, which they then fling into fish, mollusks or worms. The venom of every of the greater than 700 cone snail species is a treasure trove of chemical compounds that hijack particular physiological pathways of their prey. For instance, one cone snail species produces its personal fish insulin that saps prey’s blood sugar, making a torpid goal. (SN: 1/19/15). 

Cone snail venom homes pheromone-mimicking molecules that may be utilized by the snails to lure worms from hiding, making a neater meal.The venom’s specificity of motion has attracted drug researchers searching for inspiration. A morphinelike painkiller referred to as Prialt, for instance, stemmed from cone snails. Torres and his colleagues have been eager to scour the venom of C. imperialis, a cosmopolitan species that hunts worms, for attainable medication. Chemical evaluation revealed two compounds — Conazolium A and genuanine — that piqued the researchers’ curiosity.

To Torres’ shock, these small molecules didn’t appear to focus on neuromuscular pathways and impair their perform, like many venom constituents. However the molecules have been remarkably just like some bristle worm’s mating pheromones. Chemically, the snail’s mimics are literally extra secure than the worm’s pure pheromones, which degrade comparatively rapidly after launch, Torres says. The match appeared too excellent to be coincidental.

Whereas venom normally does its soiled work through injection, there are some examples of cone snails releasing chemical compounds into the water column. To check the lure speculation, the researchers uncovered Platynereis dumerilii worms in petri dishes to the pheromone mimics and watched. When hit with the snail chemical compounds, 13 of 16 males within the experiment launched sperm, and 7 of 11 females started swirling round in tight circles — a precursor to mating. Whereas C. imperialis isn’t recognized to eat this particular worm, the researchers discovered the DNA of shut family within the guts of some snails, suggesting that the compounds may very well be used in opposition to extra frequent prey, equivalent to fireworms.

“Cone snails are stuffed with surprises, and this paper raises an thrilling risk,” says Thomas Duda, a zoologist and evolutionary biologist on the College of Michigan in Ann Arbor who wasn’t concerned within the research. “The subsequent step must be determining how this truly works in nature.”

C. imperialis’ searching conduct is generally recognized from laboratory research, the place the worms are sitting geese for snails, Torres says. Within the wild, nonetheless, the worms spend time hidden under sediment and beneath crevices. Observations in additional pure settings may verify whether or not C. imperialis’ specialised venom entices worms with the promise of a mate, solely to develop into a meal.

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